Robert N. Baldassano research focuses on improving the care of children suffering from Inflammatory Bowel Disease. He has been instrumental in developing an international consortium for the study of the gene responsible for causing pediatric inflammatory bowel disease IBD and has chaired multiple national and international programs relating to pediatric IBD. Her clinical and research interests focus on pediatric inflammatory bowel diseases, including adolescent transitioning and quality improvement in pediatric IBD and translational research investigating the bacterial and genetic influences in IBD which has been funded by the NIH and CCFA.
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Introduction: Haemorheological and haemostatic changes predispose to the development of arterial and venous thrombotic events; however, limited information is available on the status of these changes in coeliac disease CeD and inflammatory bowel disease IBD. In this study, we aim to describe the haemorheological and haemostatic profiles of CeD and IBD patients in a Hungarian cohort of patients to investigate whether any alterations contribute to elevated thrombotic risk. Methods and analysis: This is a case-control study involving newly diagnosed and followed CeD and IBD patients with age-matched and sex-matched non-CeD, non-IBD subjects with an allocation ratio of After informed consent is obtained, a detailed medical history will be collected, including venous and arterial thrombotic risk factors and medications. Symptoms in CeD patients will be assessed with the Gastrointestinal Symptoms Rating Scale, and disease activity in IBD patients will be determined by disease-specific scores. Dietary adherence will be assessed among CeD patients with a thorough interview together with a measurement of self-reported adherence, dietary knowledge and urine analysis detection of gluten immunogenic peptides. In addition to routine laboratory parameters, haemorheological ie, erythrocyte deformability and aggregation, viscosity of whole blood and plasma and haemostatic parameters eg, protein C, protein S and antithrombin with immunological indicators ie, coeliac-specific serology and antiphospholipid antibodies will be measured from venous blood for every participant.
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Each lesson in the Disease Management Clinical Decisions series provides a brief, case-based review of management strategies related to the topic. Questions and multiple-choice answers about the case presented include the rationale for the correct answer. Throughout this case-based lesson, you may proceed to the next question once you answer the question correctly. After completing the CME activity, the evaluation, and the registration forms, you will have an opportunity to print your CME certificate for your records.
Quality of life and a role in decision making must be a priority for patients with inflammatory bowel disease, writes Niamh Hogan. Inflammatory bowel disease can be a debilitating and embarrassing illness. Patients often find it difficult to talk about their condition and symptoms. Due to the severity of the symptoms associated with IBD patients may be absent from school and work for long periods. Unfortunately the symptoms and sometimes the treatments used to manage the condition may cause side-effects such as growth retardation in children and delayed puberty in adolescents.